diff --git a/CMakeLists.txt b/CMakeLists.txt
--- a/CMakeLists.txt	(revision 86c857094a2d94fafce15a3d32abb4052e664c5c)
+++ b/CMakeLists.txt	(date 1643340236796)
@@ -409,32 +409,6 @@
     endif()
 endif()
 
-# Determine if EVP_md5_sha1 is available in libcrypto
-try_compile(
-        LIBCRYPTO_SUPPORTS_EVP_MD5_SHA1_HASH
-        ${CMAKE_BINARY_DIR}
-        SOURCES "${CMAKE_CURRENT_LIST_DIR}/tests/features/evp_md5_sha1.c"
-        LINK_LIBRARIES crypto ${OS_LIBS}
-        CMAKE_FLAGS
-            "-DINCLUDE_DIRECTORIES=$<TARGET_PROPERTY:crypto,INTERFACE_INCLUDE_DIRECTORIES>"
-)
-if (LIBCRYPTO_SUPPORTS_EVP_MD5_SHA1_HASH)
-    target_compile_options(${PROJECT_NAME} PUBLIC -DS2N_LIBCRYPTO_SUPPORTS_EVP_MD5_SHA1_HASH)
-endif()
-
-# Determine if EVP_MD_CTX_set_pkey_ctx is available in libcrypto
-try_compile(
-        LIBCRYPTO_SUPPORTS_EVP_MD_CTX_SET_PKEY_CTX
-        ${CMAKE_BINARY_DIR}
-        SOURCES "${CMAKE_CURRENT_LIST_DIR}/tests/features/evp_md_ctx_set_pkey_ctx.c"
-        LINK_LIBRARIES crypto ${OS_LIBS}
-        CMAKE_FLAGS
-            "-DINCLUDE_DIRECTORIES=$<TARGET_PROPERTY:crypto,INTERFACE_INCLUDE_DIRECTORIES>"
-)
-if (LIBCRYPTO_SUPPORTS_EVP_MD_CTX_SET_PKEY_CTX)
-    target_compile_options(${PROJECT_NAME} PUBLIC -DS2N_LIBCRYPTO_SUPPORTS_EVP_MD_CTX_SET_PKEY_CTX)
-endif()
-
 if (S2N_INTERN_LIBCRYPTO)
     if (NOT LibCrypto_STATIC_LIBRARY)
         message(FATAL_ERROR "libcrypto interning requires a static build of libcrypto.a to be available")